Brand
name: Olanzapine
Generic name: Olanzapine
Why is Olanzapine prescribed?
Olanzapine helps manage symptoms of schizophrenia, the manic phase of
bipolar disorder, and other psychotic disorders. It is thought to work
by opposing the action of serotonin and dopamine, two of the brain's
major chemical messengers. The drug is available as Olanzapine tablets
and Olanzapine Zydis, which dissolves rapidly with or without liquid.
Most important fact about Olanzapine without prescriptions
At the start of Olanzapine therapy, the drug can cause extreme low blood
pressure, increased heart rate, dizziness, and, in rare cases, a tendency
to faint when first standing up. These problems are more likely if
you are dehydrated, have heart disease, or take blood pressure medicine.
To avoid such problems, your doctor may start with a low dose of Olanzapine
and increase the dosage gradually.
How should you take Olanzapine?
Olanzapine should be taken once a day with or without food. To use Olanzapine
Zydis, open the sachet, peel back the foil on the blister pack, remove
the tablet, and place the entire tablet in the mouth. Do not push the
tablet through the foil. The medication can be taken with or without
water; the saliva in your mouth will cause the tablet to dissolve.
If you miss a dose...
Take it as soon as you remember. If it is almost time for your next
dose, skip the one you missed and go back to your regular schedule.
Do not take 2 doses at once.
-- Storage instructions --
Store at room temperature away from light and moisture.
Possible food and drug interactions when taking
Olanzapine
Avoid alcohol while taking Olanzapine. The combination can cause a
sudden drop in blood pressure.
If Olanzapine is taken with certain other drugs, the effects of either
can be increased, decreased, or altered. Ask your doctor before taking
any prescription or over-the-counter drugs. It is especially important
to check before combining Olanzapine with the following:
Blood pressure medications
Carbamazepine (Tegretol)
Diazepam (Valium)
Drugs that boost the effect of dopamine, such as the Parkinson's medications
Mirapex, Parlodel, Permax, and Requip
Fluvoxamine
Levodopa (Larodopa)
Omeprazole (Prilosec)
Rifampin (Rifadin, Rimactane)
Special information if you are pregnant or breastfeeding
If you are pregnant or plan to become pregnant, inform your doctor
immediately. Olanzapine should be used during pregnancy only if absolutely
necessary. The drug may appear in breast milk; do not breastfeed while
on Olanzapine therapy.
Olanzapine side effects
Side effects cannot be anticipated. If any develop or change in intensity,
inform your doctor as soon as possible. Only your doctor can determine
if it is safe for you to continue taking Olanzapine.
* Side effects may include:
Agitation, change in personality, constipation, dizziness, dry mouth, increased
appetite, indigestion, low blood pressure upon standing, sleepiness, tremor,
weakness, weight gain
Why should Olanzapine not be prescribed?
If Olanzapine gives you an allergic reaction, you cannot take the drug.
Special warnings about Olanzapine
Certain antipsychotic drugs, including Olanzapine, are associated with
an increased risk of developing high blood sugar, which on rare occasions
has led to coma or death. See your doctor right away if you develop
signs of high blood sugar, including dry mouth, unusual thirst, increased
urination, and tiredness. If you have diabetes or have a high risk
of developing it, see your doctor regularly for blood sugar testing.
Use Olanzapine with caution if you have any of the following conditions:
Alzheimer's disease, Parkinson's disease, trouble swallowing, narrow
angle glaucoma (high pressure in the eye), an enlarged prostate, heart
irregularities, heart disease, heart failure, liver disease, or a history
of heart attack, seizures, or intestinal blockage.
Olanzapine should not be used to treat elderly patients who have dementia
because the drug could increase the risk of stroke. In addition, antipsychotic
drug treatment has been associated with swallowing and breathing problems
in older people and those with Alzheimer's disease.
Drugs such as Olanzapine sometimes cause a condition called Neuroleptic
Malignant Syndrome (NMS). Symptoms include high fever, muscle rigidity,
irregular pulse or blood pressure, rapid heartbeat, excessive sweating,
and changes in heart rhythm. If these symptoms appear, contact your
doctor right away. You'll have to discontinue using Olanzapine while the
condition is under treatment.
There is also a risk of developing tardive dyskinesia, a condition
marked by slow, rhythmical, involuntary movements. This problem is
more likely to surface in older adults, especially elderly women. When
it does, use of Olanzapine is usually stopped.
Animal studies suggest that Olanzapine may increase the risk of breast
cancer, although human studies have not confirmed such a risk. If you
have a history of breast cancer, see your doctor regularly for checkups.
People at high risk of suicide attempts should be prescribed the lowest
dose possible to reduce the risk of intentional overdose.
Olanzapine sometimes causes drowsiness and can impair your judgment,
thinking, and motor skills. Use caution while driving and don't operate
dangerous machinery until you know how the drug affects you.
Medicines such as Olanzapine can interfere with regulation of the body's
temperature. Do not get overheated or become dehydrated while taking
Olanzapine. Avoid extreme heat and drink plenty of fluids.
Olanzapine can cause low blood pressure upon standing, resulting in dizziness,
rapid heartbeat, and fainting, especially at the start of therapy.
Let the doctor know if you develop this problem; your dosage can be
adjusted to reduce the symptoms.
If you have phenylketonuria and must avoid the amino acid phenylalanine,
you should not take Olanzapine Zydis, which contains this substance.
The safety and effectiveness of Olanzapine have not been studied in children.
Recommended dosage for Olanzapine
ADULTS
Overdosage
An overdose of Olanzapine is usually not life-threatening, but fatalities
have been reported. If you suspect an overdose, seek medical attention
immediately.
* Symptoms of Olanzapine overdose may include:
Agitation drowsiness rapid or irregular heartbeat slurred or disrupted speech
stupor
Overdoses of Olanzapine have also led to breathing difficulties, changes
in blood pressure, excessive perspiration, fever, muscle rigidity,
cardiac arrest, coma, and convulsions.
